Fluphenazine + Nortriptyline – Generic Drug Info

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Fluphenazine + Nortriptyline

Combined anxiolytics & anti-depressant drugs

Generic drug information & available brands

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AI Summary Generated by AI for informational purposes only

This combination medicine is used to treat mental conditions involving both anxiety and depression. It works to calm the mind and lift one's mood. It is generally not recommended for use during pregnancy or while breastfeeding.

Indications

This preparation is indicated in-

Mild to moderate mixed anxiety/depression
Emotional disturbance
Sleep disorder
Gastric problems

Description

Fluphenazine is a tranquilizer of the phenothiazine type. Nortriptyline is a tricyclic antidepressant having less sedative action. This combination has been found as effective preparation for the patients suffering from "anxiety" or "depression" or both and helps to restore functional ability without developing any drug dependence.

Pharmacology

Nortriptyline hydrochloride is a tricyclic antidepressant. Nortriptyline inhibits the uptake of norepinephrine and serotonin at nerve terminals. In contrast to its parent compound amitriptyline which is equally potent in inhibiting the uptake of norepinephrine and serotonin, Nortriptyline has a greater effect on norepinephrine reuptake than on serotonin reuptake.

Fluphenazine is a tranquilizer of the phenothiazine type with piperazine side chain. Fluphenazine primarily acts as a neuroleptic drug whose main therapeutic effect is believed to reside in potent dopamine (specially D2) receptor antagonism.

Dosage & Administration

Important:
Do not take any medication without a doctor's prescription. Self-medication can be dangerous.

Adults: One tablet 2 to 3 times daily.

Interaction

Interactions with barbiturates, alcohol, and narcotic drugs may occur, so central depressants should be administered with caution.

Contraindications

It is contraindicated in :

History of gradual epilepsy or organic brain damage
Blood dyscrasia
Severe cardiac insufficiency
Renal or liver damage
Patients taking monoamine oxidase inhibitor (MAOI)
Younger children
Hypersensitivity to any component of the preparation

Side Effects

Tardive dyskinesias have been reported in phenothiazine therapy; usually after prolonged courses given at doses adequately to control psychotic illness. Blood dyscrasia, Malignant Neuroleptic syndrome and sudden death have been reported rarely. Agranulocytosis is a rare but potentially fatal adverse effect of Nortriptyline Hydrochloride.

Pregnancy & Lactation

The safety in human pregnancy has not been yet established. The use of this drug in lactation is not recommended, as it is excreted in breast milk.

Precautions & Warnings

Precautions should be taken in patients with glaucoma, prostate enlargement, cardiac failure and myocardial infarction, and in concurrent administration with CNS depressants. The drug may impair alertness and abilities to drive a car or operate machinery.

Storage Conditions

Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.

The information provided on this page is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare professional before starting, stopping, or changing any medication. All brands listed might have copyright or trademark of their respective owners. Listed information may not be up-to-date or accurate. We do not guarantee the availability, quality, price or safety of any medication. Use at your own risk.

Available Brands

11 found

Brand	Strength	Type	৳
Amival Amico Laboratories Ltd.	0.5 mg+10 mg	Tablet	0.80
Anflu Alco Pharma Ltd.	0.5 mg+10 mg	Tablet	0.75
Apresin Beximco Pharmaceuticals Ltd.	0.5 mg+10 mg	Tablet	1.05
Euphor Biopharma Limited	0.5 mg+10 mg	Tablet	0.80
Flutrip General Pharmaceuticals Ltd.	0.5 mg+10 mg	Tablet	0.71
Fresh Nipa Pharmaceuticals Ltd.	0.5 mg+10 mg	Tablet	0.80
Monitol Skylab Pharmaceuticals Ltd.	0.5 mg+10 mg	Tablet	0.80
Mudibak Rephco Pharmaceuticals Ltd.	0.5 mg+10 mg	Tablet	0.75
Norflu ACME Laboratories Ltd.	0.5 mg+10 mg	Tablet	1.06
Norzin Aristopharma Ltd.	0.5 mg+10 mg	Tablet	1.05
Permival Opsonin Pharma Ltd.	0.5 mg+10 mg	Tablet	1.00

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