This preparation is indicated for the treatment and prevention of-

• Osteoarthritis
• Joint pain and inflammation
• Joint immobility and stiffness
• Rheumatoid arthritis
• Strenuous exercise and sports injury

Each tablet contains-

• Undenatured Collagen II USP 40 mg
• Glucosamine Sulfate 500 mg as Glucosamine Sulfate Potassium Chloride USP
• Chondroitin Sulfate 250 mg as Chondroitin Sulfate Sodium USP
• Methylsulfonylmethane USP 100 mg

Undenatured Collagen II is derived from chicken sternum cartilage that prevents the breakdown of bone joint cartilage by releasing collagen-specific T-regulatory cells. It also slows the production of inflammatory cytokines. The therapeutic potential of Undenatured Collagen II in joint disease depends on a specific dose of 40 mg. Glucosamine is the essential building block of joint cartilage that additionally reduces the synthesis of inflammatory and degenerative mediators responsible for the breakdown of the cartilage. Chondroitin is a structural component of cartilage that maintains water and nutrients to promote elasticity and resistance in cartilage. It protects cartilage from premature decline by preventing the matrix metalloproteinase enzyme. Methylsulfonylmethane is necessary to maintain and repair healthy joints, tendons, ligaments, and connective tissues. It reduces the expression of cyclooxygenase-2 and nitric oxide by suppressing the nuclear factor-kappa β, thus producing an analgesic and anti-inflammatory effect in reducing osteoarthritis pain and swelling. The combination of these four active ingredients gives a synergistic effect in osteoarthritis and improves joint function.

Orally 1 tablet daily after a meal or as directed by the physician.

Caution should be practised when administering this combination concomitantly with anticoagulants. Glucosamine Sulfate can alter the gastrointestinal absorption of Tetracycline, Penicillin and Chloramphenicol. This combination can be used concomitantly with analgesics or anti-inflammatory drugs.

Contraindicated in patients with known hypersensitivity to Undenatured Collagen II, Glucosamine Sulfate, Chondroitin Sulfate, and Methylsulfonylmethane. Contraindicated for patients under 18 years of age, phenylketonuria, and severe renal insufficiency.

Generally well-tolerated in the recommended dose. Occasionally mild epigastric pain, constipation, diarrhea, bloating, and nausea may occur. Rarely headache and visual disturbance may occur.

Not recommended during pregnancy and lactation.

Do not store above 30ºC, protect from light and moisture. Keep out of reach of children.