Lutisone – Fluticasone Propionate (Nasal Spray)

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Lutisone

50 mcg/spray Nasal Spray Fluocinolone & Combined Preparations, Nasal Steroid Preparations

Fluticasone Propionate (Nasal Spray) · Incepta Pharmaceuticals Ltd.

EN বাং

AI Summary Generated by AI for informational purposes only

This nasal spray treats allergy symptoms such as a stuffy or runny nose and sneezing. It helps by reducing swelling and irritation inside your nose. It is generally considered safe during pregnancy and should be used with caution while breastfeeding.

Indications

50 mcg/spray: This strength is indicated for prophylaxis and treatment of seasonal & perennial allergic rhinitis. Prevention of recurrence of nasal polyps following surgical removal.

93 mcg/spray: This strength is indicated for chronic rhinosinusitis with or without nasal polyps in adults.

Description

Fluticasone Propionate is a synthetic trifiuorinated corticosteroid with anti-inflammatory activity. It is an aqueous suspension of microfine Fluticasone Propionate for topical administration to the nasal mucosa by means of a metering, atomizing spray pump. Each bottle of Fluticasone Nasal Spray provides 120 metered sprays.

Pharmacology

Following topical administration into the nasal mucosa, Fluticasone propionate produces anti-inflammatory and vasoconstrictor effects. The exact mechanism of these actions remains unknown but may involve a reduction in the following: number of mediator cells (basophil, leukocytes and mast cells) at the epithelial level, number of eosinophils, the sensitivity of sensory nerves to mechanical stimuli, secretory response to cholinergic receptor stimulation, and fibroblast activity. Other mechanisms may involve - inhibition of capillary dilation and permeability, stabilization of lysosomal membranes and subsequent prevention of release of proteolytic enzymes.

Dosage

Fluticasone Propionate (50 mcg/spray):

Adults: 2 sprays in each nostril once daily, preferably in the morning. In some cases, 2 sprays in each nostril twice daily may be required. Total daily doses of 200 mcg (4 sprays) should not generally be exceeded.
Children (4 to 11 years of age): 1 spray in each nostril once daily. In some cases, 1 spray in each nostril twice daily may be required. Total daily doses of 100 mcg 2 sprays should not generally be exceeded.
Children below 4 years: The safety and effectiveness of Fluticasone Propionate nasal spray in children below 4 years of age have not been established.

Fluticasone Propionate (93 mcg/spray): 1 spray or 2 sprays per nostril twice daily. The maximum total daily dosage should not exceed 2 sprays in each nostril twice daily (total daily dose of 744 mcg).

Patients should use Fluticasone Propionate Nasal Spray at regular intervals as directed since its effectiveness depends on its regular use. Or as directed by the physician.

Administration

How to use the Nasal Spray-

Shake the bottle gently and remove the dust cover.
Hold the spray with your forefinger and middle finger on either side of the nozzle and your thumb underneath the bottle. Press down until a fine spray appears. If using for the first time or if you have not used it for a week or more, press the nasal applicator several times until a fine moist comes out from the container.
Gently blow the nose to clear the nostrils.
Close one nostril and carefully insert the nasal applicator into the open nostril. Tilt your head forward slightly and keep the spray upright. Breathe in through your nose and while breathing in, press the white-collar of nasal applicator firmly down once to release a spray.
Breathe out through your mouth.
Repeat the above steps in the same/ other nostril for consecutive doses.

Cleaning: The nasal spray should be cleaned at least once a week. The procedures are as follows-

Remove the dust cover.
Gently pull off the nasal applicator.
Wash the applicator and dust cover in warm water.
Shake off the excess water and leave to dry in a normal place. Avoid to apply additional heat.
Gently push the applicator back on the top of the bottle and re-fix the dust cover.

Contraindications

Fluticasone Propionate nasal spray is contraindicated in patients with a hypersensitivity to any of its ingredients.

Side Effects

Fluticasone Propionate nasal spray is absorbed less into the rest of the body, therefore fewer side effects are seen. With the nasal spray, drying of the nose and throat, unpleasant taste and smell and an increase in the incidence of nosebleeds may occur.

Pregnancy & Lactation

There are no adequate and well-controlled studies in pregnant women. Fluticasone Propionate should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known whether Fluticasone Propionate is excreted in human breast milk. Because other corticosteroids are excreted in human milk, caution should be exercised when Fluticasone Propionate nasal spray is administered to a nursing woman.

Precautions & Warnings

Rare instances of wheezing, nasal septum perforation, cataracts, glaucoma and increased intraocular pressure have been reported following the intranasal application of corticosteroids, including Fluticasone Propionate. Although systemic effects have been minimal with recommended doses of Fluticasone Propionate nasal spray. Potential risk increases with larger doses. Therefore, larger than recommended doses of Fluticasone Propionate nasal spray should be avoided.

Storage Conditions

Keep all medicines out of reach of the children. Store in a cool and dry place protected from light.

The information provided on this page is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare professional before starting, stopping, or changing any medication. All brands listed might have copyright or trademark of their respective owners. Listed information may not be up-to-date or accurate. We do not guarantee the availability, quality, price or safety of any medication. Use at your own risk.

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