Arthera – Iguratimod

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Arthera

25 mg Tablet Disease-modifying antirheumatic drugs (DMARDs)
Iguratimod · Incepta Pharmaceuticals Ltd.
EN বাং
৳35.00
per unit
AI Summary Generated by AI for informational purposes only

এই ওষুধটি রিউমাটয়েড আর্থ্রাইটিস বা বাত রোগের চিকিৎসার জন্য ব্যবহৃত হয়, যা জয়েন্টে ব্যথা এবং ফোলা সৃষ্টি করে। এটি প্রদাহ কমিয়ে জয়েন্টের ক্ষতি রোধ করতে সাহায্য করে। গর্ভাবস্থায় এর ব্যবহার নিরাপদ নয় এবং স্তন্যদানকালে এটি ব্যবহারের পরামর্শ দেওয়া হয় না।

Indications

Iguratimod tablet is indicated for the treatment of rheumatoid arthritis (RA), a common autoimmune disease. It is a synthetic disease-modifying antirheumatic drug (csDMARD) that has also shown promise in treating other rheumatic and autoimmune conditions, including Sjögren's syndrome, ankylosing spondylitis, and systemic lupus erythematosus (SLE).

Pharmacology

Immunomodulatory Effects: Iguratimod works by acting on both T and B lymphocytes to suppress the immune response.  

Anti-inflammatory Action: It inhibits the production of pro-inflammatory cytokines, such as TNF-α, IL-1β, IL-6, and IL-17, which contribute to inflammation.  

Osteoprotective Activity: Iguratimod promotes bone formation while inhibiting the differentiation and activity of bone-resorbing osteoclasts.

Dosage & Administration

Important:
Do not take any medication without a doctor's prescription. Self-medication can be dangerous.
Usual Adult Dose (Rheumatoid Arthritis):
  • 25 mg orally twice daily (morning and evening) after meals.
  • In some cases, physicians may start with 25 mg once daily for 1-2 weeks to improve tolerance, then increase to 25 mg twice daily.
Notes:
  • Dose adjustments are usually not required in mild renal/hepatic impairment, but the drug should be used with caution.
  • It is not typically recommended for children (safety and efficacy not established).
  • Regular monitoring of liver function, renal function, and blood counts is required.
  • Often used alone or in combination with methotrexate or other DMARDs.

Contraindications

  • Hypersensitivity to Iguratimod or formulation components.
  • Severe hepatic impairment.
  • Pregnancy and breastfeeding (teratogenic risk and not enough safety data).

Side Effects

Common side effects
  • Gastrointestinal: nausea, stomach pain, diarrhea, indigestion
  • General: headache, dizziness, tiredness
  • Laboratory findings: mild increase in liver enzymes (ALT, AST), sometimes mild decrease in blood counts

Precautions & Warnings

Liver toxicity
  • May cause elevated liver enzymes (ALT, AST).
  • Requires regular liver function tests (LFTs) (baseline, then periodically).
  • Stop if significant hepatotoxicity occurs.
Bone marrow suppression
  • Can cause leukopenia, neutropenia, anemia, or thrombocytopenia.
  • Monitor CBC regularly.
Renal impairment
  • Use with caution; monitor renal function.
Infections
  • Being an immunomodulator, it can increase risk of infections (respiratory, urinary, etc.).
  • Avoid use in patients with active infections (e.g., TB, hepatitis).
Gastrointestinal effects
  • Nausea, dyspepsia, diarrhea may occur.
  • Take after meals to reduce GI upset.
Pregnancy & breastfeeding
  • Contraindicated; may cause fetal harm.
  • Effective contraception is required during treatment and for some time after discontinuation.
Drug interactions
  • Use caution with other immunosuppressants, DMARDs, hepatotoxic drugs, or anticoagulants.
  • Combination with methotrexate is common but needs close monitoring.

Storage Conditions

Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.

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