AI Summary
Generated by AI for informational purposes only
এটি উচ্চ রক্তচাপ কমানোর একটি ওষুধ। এটি রক্তনালীকে প্রসারিত করে, ফলে হার্টের পক্ষে সারা শরীরে রক্ত পাম্প করা সহজ হয়। গর্ভাবস্থায় এবং স্তন্যদানকালে এটি সাধারণত ব্যবহারের জন্য সুপারিশ করা হয় না।
Indications
Lacidipine is indicated for the treatment of hypertension, either alone or in combination with other antihypertensive agents such as beta-blockers and diuretics.
Pharmacology
Lacidipine inhibits the influx of calcium into smooth muscle cells by the competitive inhibition of voltage-dependent calcium 'L' channels. This action results in the inhibition of the effects triggered by the influx of calcium into the cells, such as the activation of the contractile proteins in smooth muscle.
Dosage & Administration
Important: Do not take any medication without a doctor's prescription. Self-medication can be dangerous.
Initially 2 mg as a single daily dose, preferably in the morning; increased after 3-4 weeks to 4 mg daily, then if necessary to 6 mg.
Interaction
Cimetidine increases the concentration of Lacidipine. Lacidipine increases the concentration of Digoxin & Propranolol but Propranolol decreases the maximum concentration & AUC of Lacidipine.
Contraindications
Hypersensitivity to dihydropyridine derivatives. Cardiogenic shock, aortic stenosis, avoid within 1 month of myocardial infarction, impaired left ventricular function, pregnancy and breast-feeding.
Use in neonates: There are no data on safety or efficacy of Lacidipine in neonates.
Use in children: Treatment with Lacidipine have not been evaluated in Children.
Use in nursing mothers: Milk transfer studies showed that Lacidipine is excreted into breast milk and therefore, Lacidipine should not be used during lactation.
Use in pregnancy: Although no teratogenic effect of Lacidipine has been established in animals, there are no data on the safety of Lacidipine in human pregnancy; therefore it is contraindicated.
Precautions & Warnings
Cardiac conduction abnormalities, poor cardiac reserve, hepatic impairment, withdraw if ischemic pain occurs shortly after initiating treatment or if cardiogenic shock develops, avoid grapefruit juice (may affect metabolism).
Overdose Effects
Symptoms: Prolonged peripheral vasodilation associated with hypotension and tachycardia, bradycardia or prolonged AV conduction.
Management: Symptomatic and supportive treatment.
Storage Conditions
Store in a cool and dry place, protect from light and moisture. Keep out of the reach of children.
The information provided on this page is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
Always consult a qualified healthcare professional before starting, stopping, or changing any medication.
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