Lotenate Plus – Loteprednol Etabonate + Tobramycin

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Lotenate Plus

0.5%+0.3% Ophthalmic Suspension Ophthalmic steroid - antibiotic combined preparations
Loteprednol Etabonate + Tobramycin · Pacific Pharmaceuticals Ltd.
EN বাং
AI Summary Generated by AI for informational purposes only

এই চোখের ড্রপটি ব্যাকটেরিয়াজনিত চোখের সংক্রমণ ও প্রদাহের জন্য ব্যবহৃত হয়। এটি জীবাণু মারার ঔষধ এবং ফোলা ও লাল ভাব কমানোর ঔষধের একটি মিশ্রণ। গর্ভাবস্থায় বা বুকের দুধ খাওয়ানোর সময় শুধুমাত্র ডাক্তারের পরামর্শে ব্যবহার করতে হবে।

Antibiotic — Prescription Required

This medicine is an antibiotic. It must only be used under a doctor's prescription. Misuse or incomplete courses can lead to antibiotic resistance and serious health risks.

Indications

This combination ophthalmic suspension is indicated for steroid-responsive inflammatory ocular conditions for which a corticosteroid is indicated and where superficial bacterial ocular infection or a risk of bacterial ocular infection exists. Ocular steroids are indicated in inflammatory conditions of the palpebral and bulbar conjunctiva, cornea and anterior segment of the globe such as allergic conjunctivitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis. It is also indicated in chronic anterior uveitis and corneal injury from chemical, radiation or thermal burns, or penetration of foreign bodies. This is also indicated for the treatment of post-operative inflammation following ocular surgery.

Pharmacology

Loteprednol is a corticosteroid which is thought to act by the induction of phospholipase A2 inhibitory proteins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid.

Tobramycin is a member of aminoglycoside which shows bactericidal activity by inhibiting protein synthesis of bacteria.

Dosage & Administration

Important:
Do not take any medication without a doctor's prescription. Self-medication can be dangerous.
Shake well before use. Apply one drop into the conjunctival sac of the affected eye(s) every four to six hours. During the initial 24 to 48 hours, the dosing may be increased, to every one to two hours.

Interaction

Since Loteprednol Etabonate is not detected in plasma following the topical administration, it is not expected to affect the pharmacokinetics of systemically administered medicinal products.

Contraindications

Contraindicated in most viral diseases of the cornea and conjunctiva. Also contraindicated in individuals with known or suspected hypersensitivity to any of the ingredients of this preparation and to other corticosteroids.

Side Effects

Increased intraocular pressure, burning and stinging upon instillation, vision disorders, discharge, itching, lacrimation disorder, photophobia, corneal deposits, ocular discomfort, eyelid disorder, and other unspecified eye disorders may occur. The incidence of non-ocular adverse events (headache) also reported.

Pregnancy & Lactation

Use in pregnancy: There are no adequate and well-controlled studies in pregnant women. Loteprednol Etabonate & Tobramycin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Use in lactation: Caution should be exercised when Loteprednol Etabonate & Tobramycin is administered to a nursing mother.

Precautions & Warnings

  • For ophthalmic use only.
  • If this product is used for 10 days or longer, intraocular pressure should be monitored.
  • Fungal infections of the cornea are particularly prone to develop coincidentally with long-term use of steroid topically.
  • Prolonged use may result in overgrowth of nonsusceptible organisms including fungi. If superinfection occurs, appropriate therapy should be initiated.
  • Cross-sensitivity to other aminoglycoside antibiotics may occur.

Use in Special Populations

Use in children: Safety and effectiveness in pediatric patients have not been established.

Storage Conditions

Store at room temperature & protect from light. Do not touch dropper tip to any surface. It is desirable that the contents should not be used four weeks after first opening of the bottle. Protect from freezing.

The information provided on this page is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare professional before starting, stopping, or changing any medication. All brands listed might have copyright or trademark of their respective owners. Listed information may not be up-to-date or accurate. We do not guarantee the availability, quality, price or safety of any medication. Use at your own risk.

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