AI Summary
Generated by AI for informational purposes only
This is an antifungal medicine applied to the skin as a cream or gel. It treats skin infections like athlete's foot, ringworm, and jock itch. It should be used during pregnancy or while breastfeeding only if a doctor advises it.
Indications
Naftifine cream is an allylamine antifungal indicated for the treatment of interdigital tinea pedis, tinea cruris, and tinea corporis caused by the organism Trichophyton Rubrum.
Description
Naftifine is a synthetic, broad spectrum, antifungal agent and allylamine derivative. The following in vitro data are available, but their clinical significance is unknown. Naftifine has been shown to exhibit fungicidal activity in vitro against a broad spectrum of organisms including Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton tonsurans, Epidermophyton floccosum, and Microsporum canis, Microsporum audouini, and Microsporum gypseum; and fungistatic activity against Candida species including Candida albicans. However it is only used to treat the organisms listed in the indications.
Pharmacology
The exact mechanism of action against fungi is not known, Naftifine Hydrochloride appears to interfere with sterol biosynthesis by inhibiting the enzyme squalene 2, 3-epoxidase. This inhibition of enzyme activity results in decreased amounts of sterols, especially ergosterol and a corresponding accumulation of squalene in the cells.
Dosage & Administration
Important: Do not take any medication without a doctor's prescription. Self-medication can be dangerous.
Apply a thin layer of Naftifine Hydrochloride Cream once-daily to the affected areas plus half inch margin of healthy surrounding skin for 2 weeks or as directed by the physician.
Use in Children and Adolescents: The safety and effectiveness of Naftifine Hydrochloride have been established in the age group of 12-17 years with interdigital tinea pedis and tinea cruris.
Interaction
No information is available.
Side Effects
The most common adverse reaction (≥1%) is pruritus.
Pregnancy & Lactation
Pregnancy Category B. There are no adequate and well-controlled studies of Naftifine Cream in pregnant women. Because animal reproduction studies are not always predictive of human response, Naftifine Cream should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Naftifine Cream is administered to a nursing woman.
Precautions & Warnings
If irritation or sensitivity develops with the use of Naftifine Hydrochloride Cream, treatment should be discontinued.
Overdose Effects
An overdose of Naftifine topical is not expected to be dangerous.
Storage Conditions
Store below 30°C, away from light and in a dry place. Keep out of the reach of children.
The information provided on this page is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
Always consult a qualified healthcare professional before starting, stopping, or changing any medication.
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