AI Summary
Generated by AI for informational purposes only
This is a combination eye drop used to lower increased pressure inside the eye. It is prescribed for conditions like glaucoma to help prevent vision loss. It should be used with caution during pregnancy and breastfeeding.
Indications
This is indicated for the reduction of elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension.
Pharmacology
This is a fixed-dose combination of a Rho kinase inhibitor and a Prostaglandin F2 analogue. Netarsudil is a Rho kinase inhibitor, works at the cellular level within the trabecular outflow pathway to relax actin-myosin. This causes relaxation within the trabecular meshwork and the inner wall of Schlemm's canal, and decrease episcleral venous pressure (EVP).
Latanoprost is a selective FP receptor agonist which reduces the intraocular pressure (IOP) by increasing the outflow of aqueous humor through uveoscleral outflow.
Dosage & Administration
Important: Do not take any medication without a doctor's prescription. Self-medication can be dangerous.
The recommended dosage is one drop in the affected eye(s) once daily in the evening.
Contraindications
This eye drops is contraindicated in patients who are hypersensitive to any component of this preparation.
Side Effects
The most common ocular adverse reaction observed in controlled clinical studies with Netarsudil & Latanoprost was conjunctival hyperemia, instillation site pain, corneal verticillata, instillation site discomfort, foreign body sensation and blurred visions were reported in few patients.
Pregnancy & Lactation
There are no adequate and well-controlled studies of Netarsudil & Latanoprost combination in pregnant women to inform any drug-associated risk. There are no data on the presence of Netarsudil or Latanoprost in human milk, the effects on the breastfed infant, or the effects on milk production.
Precautions & Warnings
For ophthalmic use only
To avoid possible contamination of the drops, do not touch the dropper tip or to any surface
Should be used with caution in patients with active intraocular inflammation (e.g., iritis/uveits)
May cause changes to pigmented tissues, gradually change eyelashes and vellus hair in the treated eye
Cystoid macular edema, has been reported during treatment with Latanoprost. Reactivation of Herpes Simplex keratitis may occur
Netarsudil & Latanoprost combination can be used with other topical eye drug products, but they should be administered at least 5 minutes apart from each other.
Use in Special Populations
Pediatric Use: Safety and effectiveness in pediatric patients have not been established.
Use in elderly patients: No overall differences in safety and effectiveness have been observed between elderly and other adult patients.
Storage Conditions
Store at 2°-8°C in a dry place, protect from light until opened. After opening the product may be kept at 2°-25°C for upto 6 weeks. Keep out of the reach of children.
The information provided on this page is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
Always consult a qualified healthcare professional before starting, stopping, or changing any medication.
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