Nikethamide – Nikethamide

Home / Nikethamide – Nikethamide

Nikethamide

250 mg/ml Injection Respiratory stimulants: analeptics
Nikethamide · Jayson Pharmaceutical Ltd.
EN বাং
AI Summary Generated by AI for informational purposes only

এটি শ্বাসতন্ত্রকে উদ্দীপিত করে শ্বাস-প্রশ্বাস বাড়াতে সাহায্য করে। নিরাপত্তার কারণে এর ব্যবহার এখন অনেক সীমিত। গর্ভাবস্থায় বা বুকের দুধ খাওয়ানোর সময় এটা নিরাপদ নয়।

Indications

Nikethamide is indicated in-
  • Acute respiratory failure
  • Respiratory depression following anesthesia
  • CNS depression

Pharmacology

Nikethamide also known as nicotinic acid diethylamide is a central & respiratory stimulant. It has direct stimulatory action on CNS, increases the frequency & depth of breathing. It has no immediate impact on the cardiovascular system. It is extensively metabolized in liver. All metabolites & a small amount of unchanged drug is excreted in urine.

Dosage & Administration

Important:
Do not take any medication without a doctor's prescription. Self-medication can be dangerous.
2 to 10 mL by slow IV injection of the usual 25% solution every 20 to 30 minutes if necessary. Infants and children are particularly susceptible to toxic effects of nikethamide.

Interaction

Anesthetic, sympathomimetics, MAOIs, neuromuscular blockers, bupropion.

Contraindications

Porphyria, epilepsy or other convulsive disorders, perebral oedema, airways obstruction, cerebrovascular accident, severe hypertension & ischemic heart diseases.

Side Effects

Dyspnoea, respiratory problems such as coughing bronchospasm. Other CNS side effects include convulsion, headache & dizziness. Cardiovascular side effects inlude Iteration of blood pressure & cardiac arrhythmia. Over dosage may cause nausea, vomiting & diarrhoea.

Pregnancy & Lactation

There are no enough adequate and controlled studies in pregnant women and nursing mothers.

Precautions & Warnings

It should not used in less severe degrees of hypertension or impaired cardiac reverse & hepatic dysfunction.

Storage Conditions

Store below 25°C in a dry place, away from light.

The information provided on this page is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare professional before starting, stopping, or changing any medication. All brands listed might have copyright or trademark of their respective owners. Listed information may not be up-to-date or accurate. We do not guarantee the availability, quality, price or safety of any medication. Use at your own risk.