AI Summary
Generated by AI for informational purposes only
এই ঔষধটি মারাত্মক ঘুমের সমস্যার স্বল্পমেয়াদী চিকিৎসার জন্য ব্যবহৃত হয়। এটি মস্তিষ্ককে শান্ত করে ঘুমাতে সাহায্য করে। গর্ভাবস্থায় বা বাচ্চাকে দুধ খাওয়ানোর সময় এটি ব্যবহার করা সাধারণত নিরাপদ নয়।
Indications
Nitrazepam is indicated in disturbances of sleep of various aetiology, insomnia of the neurotics, involutional restlessness, disturbances of sleep of cerebrosclerotic patients, Myoclonic seizures etc.
Pharmacology
Nitrazepam is a benzodiazepine derivative nearly related to diazepam. Contrary to barbiturate derivatives Nitrazepam gives free way to physiologic sleep by increasing the stimulus threshold of hypocampus and does not inhibit cortical function. After a sleep with Nitrazepam patients awaken thoroughly relaxed.
Dosage & Administration
Important: Do not take any medication without a doctor's prescription. Self-medication can be dangerous.
Treatment of insomnia is usually initiated with a dose of 5 mg at night although 2.5 mg is appropriate in elderly patient. The dose may be increased to 10 mg at night if insomnia is severe.
Myoclonic seizures: Children: (up to 30 kg of body weight) between 0.3 and 1.0 mg/kg/day given in 3 divided doses. Treatment should be initiated with lower dose than the usual recommended dosage range in order to determine tolerance and response.
Dosage should be individualized for maximal beneficial effect.
Interaction
CNS depressant effect increased with alcohol, barbiturates, TCAs, phenothiazines, morphine derivatives. Effects may be antagonised by theophylline. Increased levels/effects with probenecid. Reduced levels/effects with rifampicin. May reduce effects of levodopa.
Contraindications
It is not recommended to use Nitrazepam during the first three months of the pregnancy. In myasthenia gravis, administration of Nitrazepam is contra-indicated.
Side Effects
Patients do not show additional symptoms even after a prolonged treatment.
Precautions & Warnings
To be dispensed only by or on the prescription of a registered physician. To be taken as directed by physician. Keep out of reach of children. Keep in a cool & dry place.
Management: Supportive. Gastric lavage may be beneficial if performed soon after ingestion. Flumazenil may reverse benzodiazepine-induced CNS depression.
Storage Conditions
Store at room temperature. Protect from light and moisture.
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Always consult a qualified healthcare professional before starting, stopping, or changing any medication.
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