Omaglip – Omarigliptin

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Omaglip

25 mg Tablet Dipeptidyl Peptidase-4 (DPP-4) inhibitor

Omarigliptin · Navana Pharmaceuticals Ltd.

EN বাং

৳140.00

per unit

AI Summary Generated by AI for informational purposes only

This medicine is used to control high blood sugar in people with type 2 diabetes. It works by helping the body produce more insulin after a meal. It is generally not recommended for use during pregnancy or while breastfeeding.

Indications

Omarigliptin is indicated for the treatment of adults with type 2 diabetes.

Pharmacology

Omarigliptin is a long-acting inhibitor of the enzyme dipeptidyl peptidase-4 (DPP- 4). DPP-4 rapidly degrades incretin hormones. Incretins lower blood glucose concentrations in response to a meal by increasing insulin and decreasing glucagon levels in a glucose-dependent manner. Thus, Omarigliptin's mechanism of action augments the action of incretin hormones.

Dosage & Administration

Important:
Do not take any medication without a doctor's prescription. Self-medication can be dangerous.

Route of administration: Omarigliptin tablets should be taken in oral route.

Recommended dosage: The recommended dose of Omarigliptin is 25 mg once weekly as monotherapy or as add-on therapy for optimisation of glycemic control. If patient misses a dose, advice to take the missed dose as soon as possible and then follow the regular weekly dosing schedule. Never take two doses at one time.

Renal impairment: The dosage in patients with severe renal dysfunction or with end-stage renal failure or in those requiring hemodialysis or peritoneal dialysis should be according to the following:

Severe end-stage kidney failur-

Men: CrCl>1.9: 12.5 mg once a week
Women: CrCl >1.4: 12.5 mg once a week.

Use in children and adolescents: Safety and efficacy of omarigliptin in children and adolescents have not been established.

Interaction

Drug interaction with medication: Omarigliptin interacts with metformin, glimepiride, oral contraceptives and atorvastatin. Other anti-diabetic drugs (in particular, insulin preparation or sulfonylurea) should be used with caution in combination with omarigliptin, as they may cause hypoglycemia. Precaution must be taken with drugs that enhances the hypoglycemic action (3-blockers, salicylic acid agents, monoamine oxidase inhibitors). Blood glucose level should be carefully monitored when using drugs that attenuate the hypoglycemic action (adrenaline, adrenocorticotropic hormone, thyroid hormone).

Contraindications

Omarigliptin is contraindicated in patients with hypersensitivity to omarigliptin or any other component of this product. It is also contraindicated in severe ketosis, diabetic coma or precoma in type 1 diabetes patients. Omarigliptin is contraindicated in severe infection in which glycemic control is desired by insulin injection, before and after surgery and in patients with severe trauma.

Side Effects

The adverse effects of omarigliptin are generally well tolerated. The most common side effects are nasopharyngitis, hypoglycemia, constipation, diarrhea, gastrointestinal problem, skin and subcutaneous tissue disorders.

Pregnancy & Lactation

Clinical trials on use of omarigliptin in pregnant women have not been performed. It should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Breastfeeding should be avoided in mothers taking omarigliptin.

Precautions & Warnings

Omarigliptin should be administered with caution in following patients or conditions which might cause low blood sugar such as pituitary dysfunction or adrenal insufficiency; malnutrition, starvation, irregular dietary intake, lack of dietary intake or debilitated state; intense muscle movement; excessive alcohol intake and elder person. Caution should be taken in patients engaged in aerial work or operation of an automobile.

Overdose Effects

No data is available regarding overdose of omarigliptin. In the event of overdosage, supportive care is advised.

Storage Conditions

Store in a cool (below 30°C) & dry place protected from the light. Keep away from the reach of children.

The information provided on this page is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare professional before starting, stopping, or changing any medication. All brands listed might have copyright or trademark of their respective owners. Listed information may not be up-to-date or accurate. We do not guarantee the availability, quality, price or safety of any medication. Use at your own risk.

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