Racetril

10 mg/sachet Oral Powder Anti-diarrhoeal
Racecadotril · Incepta Pharmaceuticals Ltd.
EN বাং
AI Summary Generated by AI for informational purposes only

This medicine is used to treat the symptoms of sudden, severe diarrhea. It works by reducing the amount of water your body loses in the stool. It is generally not recommended for use during pregnancy or breastfeeding.

Indications

Racecadotril is indicated as an adjunct to rehydration therapy for the symptomatic treatment of acute secretory diarrhea.

Pharmacology

Racecadotril is a prodrug that needs to be hydrolysed to its active metabolite thiorphan. Thiorphan is an inhibitor of enkephalinase. Enkephalinase is a cell membrane peptidase located in various tissues, notably in the epithelium of the small intestine. This enzyme hydrolyses or breaks down the exogenous peptides and endogenous peptides (enkephalins). Racecadotril protects enkephalins from enzymatic degradation thereby prolonging their action at enkephalinergic synapses in the small intestine and reducing water and electrolytes hypersecretion. Racecadotril exerts rapid antidiarrheal action, without modifying the duration of intestinal transit. Racecadotril does not produce abdominal distension.

Dosage & Administration

Important:
Do not take any medication without a doctor's prescription. Self-medication can be dangerous.
Adults: One capsule initially regardless of the time of the day; then one capsule 3 times daily (preferable before food) untill diarrhea stops.

Children (3 months to 18 years): Racecadotril is suitable for children over 3 months of age. 
  • Recommended dose is 1.5 mg/kg body weight.
  • If Body weight less than 9 kg: 10 mg 3 times daily.
  • If Body weight 9-13 kg: 20 mg 3 times daily.
  • If Body weight 13-27 kg: 30 mg 3 times daily.
  • If Body weight over 30 kg: 60 mg 3 times daily.
Maximum duration of treatment is 7 days.

How to use sachet:
  • Dissolve the powder in 20 ml pure water
  • Stir well
  • After dissolving the powder drink full suspension immediately

Interaction

No interactions with other active substances have been described in humans to date. In humans, joint treatment with Racecadotril and Loperamide or Nifuroxazide does not modify the kinetics of Racecadotril.

Contraindications

Racecadotril is contraindicated in patients who have shown hypersensitivity to its components.

Side Effects

Headache, rash and erythema.

Pregnancy & Lactation

Due to a lack of clinical data, Racecadotril should not be administered to pregnant or breastfeeding women.

Precautions & Warnings

The administration of Racecadotril does not modify the usual rehydration regimens. There are limited data in patients with renal or hepatic impairment. So these patients should be treated with caution.

Overdose Effects

No cases of overdose have been reported. In adults, single doses above 2 g which is equivalent to 20 times the therapeutic dose, have been administered, and no harmful effects have been described.

Storage Conditions

Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.

The information provided on this page is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare professional before starting, stopping, or changing any medication. All brands listed might have copyright or trademark of their respective owners. Listed information may not be up-to-date or accurate. We do not guarantee the availability, quality, price or safety of any medication. Use at your own risk.

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