Cotrazen DS – Sulphamethoxazole + Trimethoprim

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Cotrazen DS

800 mg+160 mg Tablet Anti-diarrhoeal Antimicrobial drugs, Sulphonamides & Trimethoprim
Sulphamethoxazole + Trimethoprim · Zenith Pharmaceuticals Ltd.
EN বাং
৳2.02
per unit
AI Summary Generated by AI for informational purposes only

এটি একটি অ্যান্টিবায়োটিক যা বিভিন্ন জীবাণু সংক্রমণ যেমন প্রস্রাবের রাস্তায়, ফুসফুসে বা কানের ইনফেকশনের চিকিৎসায় ব্যবহৃত হয়। গর্ভাবস্থায় এটি সাধারণত নিরাপদ নয় এবং স্তন্যদানকালে সতর্কতার সাথে ব্যবহার করতে হবে।

Antibiotic — Prescription Required

This medicine is an antibiotic. It must only be used under a doctor's prescription. Misuse or incomplete courses can lead to antibiotic resistance and serious health risks.

Indications

Cotrimoxazole is bactericidal in vitro to a wide range of Gram-positive and Gram-negative organisms, including Streptococcus, Staphylococcus, Pneumococcus, Neisseria, B. catarrhalis, Escherichia coli, Klebsiella, Proteus spp., Haemophilus, Salmonella, Shigella, Vibrio cholerae, Brucella, Pneumocystis carinii, Nocardia and Bordetella. A particularly high degree of activity is exhibited against Haemophilus influenzae, E. coli and Proteus spp., making Cotrimoxazole particularly suitable for the treatment of chronic bronchitis and urinary tract infections. Cotrimoxazole exerts its bactericidal action by the sequential blockade of two bacterial enzyme systems in the biosynthesis of Folinic acid in the micro-organisms. The synergy thus produced accounts for the high degree of bactericidal activity.

This combination is indicated in:
  • Respiratory tract infections, including acute and chronic bronchitis (treatment and prophylaxis), bronchiectasis, lung abscess, lobar and broncho-pneumonia, Pneumocystis carinii pneumonitis, sinusitis and otitis media.
  • Genito-urinary tract infections, including urethritis, acute and chronic cystitis, pyelonephritis, prostatitis and gonorrhoea.
  • Gastro-intestinal tract infections, caused by Salmonella typhi and Salmonella paratyphi, including the chronic carrier state.
  • Other infections, caused by a wide range of organisms confirmed to be susceptible to Cotrimoxazole and where the therapeutic benefits are considered to outweigh the possible occurrence of adverse events.
  • Such infections include acute and chronic osteomyelitis, acute brucellosis, skin infections including pyoderma, abscesses and wound infections, septicaemia, bacillary dysentery and cholera (as an adjuvant to fluid and electrolyte replacement), nocardiosis and mycetoma.

Pharmacology

Cotrimoxazole having broad spectrum bactericidal activity against a wide range of gram-positive & gram-negative bacteria and some protozoa. Co-trimoxazole containing Trimethoprim and Sulphamethoxazole in a 1:5 combination exerts its bactericidal action by the sequential blockade of two bacterial enzyme systems in the biosynthesis of folinic acid in the microorganism.

Dosage & Administration

Important:
Do not take any medication without a doctor's prescription. Self-medication can be dangerous.
Cotrimoxazole double strength tablet: Over 12 years
  • For mild to moderate infections: 1 tablet twice daily.
  • For severe infections: 1.5 tablets twice daily.
  • Long term therapy (>14 days): 0.5 tablet twice daily.
  • Gonorrhoea: 2 tablets every 12 hours for two days or 2.5 tablets followed by a further dose of 2.5 tablets after 8 hours.
Cotrimoxazole tablet: over 12 years
  • For mild to moderate infections: 2 tablets twice daily.
  • For severe infections: 2 tablets thrice daily.
  • Long term therapy: (>14 days): 1 tablet twice daily.
Cotrimoxazole suspension: Under 12 years
  • 6-12 years: 2 teaspoonful twice daily.
  • 6 month-5 years: 1 teaspoonful twice daily.
  • 6 weeks-6 months: 0.5 teaspoonful twice daily.

Contraindications

  • Hypersensitivity to trimethoprim or sulphonamides.
  • Patients with documented megaloblastic anaemia due to folate deficiency.
  • Patients showing marked liver parenchymal damage, blood dyscrasia, severe renal insufficiency, glucose 6-phosphate dehydrogenase deficiency.

Side Effects

The side effects like crystalluria, allergic reactions, haemolysis, thrombocytopenia, neutropenia, agranulocytosis etc. have been reported rarely with Sulphamethoxazole-Trimethoprim combination. Other side effects are less serious in nature such as malaise, headache, nausea and vomiting. These are normally transient and do not require withdrawal of treatment.

Pregnancy & Lactation

Pregnancy and during the nursing period, because sulphonamides pass the placenta and are excreted in the breast milk and may cause kernicterus.

Precautions & Warnings

Prolonged full dose treatment with sulfamethoxazole-trimethoprim combination is associated with the risk of macrocytic anaemia due to the drug’s interference in the conversion of Folic acid into Folinic acid. If this occurs, it can be reversed by giving Folinic acid. Care should be taken when giving this combination to diabetic patients receiving sulphonylurea drug for possible potentiation of action of sulphonylurea.

Storage Conditions

Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.

The information provided on this page is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare professional before starting, stopping, or changing any medication. All brands listed might have copyright or trademark of their respective owners. Listed information may not be up-to-date or accurate. We do not guarantee the availability, quality, price or safety of any medication. Use at your own risk.

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