AI Summary
Generated by AI for informational purposes only
This is a pain reliever made from chili peppers that is applied to the skin. It is used to relieve minor muscle aches, joint pain, and nerve pain. It is generally considered safe during pregnancy but consult a doctor before use while breastfeeding.
Indications
Capsaicin is indicated for the symptomatic relief of pain associated with osteoarthritis and rheumatoid arthritis.
Pharmacology
Although the precise mechanism of action of Capsaicin is not fully understood, current evidence suggests that Capsaicin exerts an analgesic effect by depleting and preventing reaccumulation of Substance P in peripheral sensory neurons. Substance P is thought to be the principal chemomediator of pain impulses from the periphery to the central nervous system.
Absorption after topical application is unknown. Capsaicin content in capsicum fruit is approximately 1% therefore dietary intake of Capsaicin may range from 0.5-1mg/kg/day for a 50kg person. Application of 90 gm of Capsaicin cream 0.025% each week results in 3.21mg/day topical exposure. Assuming 100% absorption in a 50kg person, daily exposure would be 0.064mg/kg which is approximately one eighth of the above mentioned dietary intake.
Dosage & Administration
Important: Do not take any medication without a doctor's prescription. Self-medication can be dangerous.
18 years of age and older: Apply a thin film of Capsaicin cream to affected area 3 to 4 times daily. A burning sensation may occur upon application, but generally disappears with regular use. Application schedules of 3 to 4 times a day for 2 weeks provides optimum pain relief.
Contraindications
Capsaicin cream is contraindicated on broken or irritated skin. It is also contraindicated in patients with known hypersensitivity to capsaicin or any of the excipients used in this product.
Side Effects
Transient burning sensation may occur during initial treatment, particularly if too much cream is used or if the frequency of administration is less than 3-4 times daily. This burning sensation generally disappears after several days of treatment.
Pregnancy & Lactation
The safety of Capsaicin during pregnancy and lactation has not been established, in either humans or animals. However, in the small amounts absorbed transdermally from Capsaicin cream, it is considered unlikely that Capsaicin will cause any adverse effects in humans.
Precautions & Warnings
Avoid taking a hot shower or bath just before or after applying Capsaicin burning sensation may enhance. Hands should be washed immediately after use. Not for use under tight bandages.
Storage Conditions
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
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