Duo-5 – Cefpodoxime Proxetil + Clavulanic Acid

Home / Duo-5 – Cefpodoxime Proxetil + Clavulanic Acid

Duo-5

200 mg+125 mg Tablet Third generation Cephalosporins
Cefpodoxime Proxetil + Clavulanic Acid · Incepta Pharmaceuticals Ltd.
EN বাং
৳50.00
per unit
AI Summary Generated by AI for informational purposes only

This is a combination antibiotic used for bacterial infections of the ears, throat, lungs, and skin. The added ingredient helps the main medicine fight resistant bacteria more effectively. It should be used during pregnancy only if clearly needed and with caution while breastfeeding.

Antibiotic — Prescription Required

This medicine is an antibiotic. It must only be used under a doctor's prescription. Misuse or incomplete courses can lead to antibiotic resistance and serious health risks.

Indications

It is indicated in the following infections -
  • Acute bacterial exacerbation of chronic bronchitis
  • Acute community acquired pneumonia
  • Pharyngitis or tonsillitis
  • Skin and soft tissue infections
  • Urinary tract infections
  • Uncomplicated gonorrhea
  • Acute maxillary sinusitis

Pharmacology

Cefpodoxime is a third generation semi-synthetic Cephalosporin, exhibits activity against several Gram positive as well as Gram negative microorganisms. This compound is also stable in beta lactamase environment. Cefpodoxime exhibits exceptional activity against methicillin susceptible Staphylococci, Streptococcus pneumoniae, Haemophilus influenzae, Neisseria spp. and Moraxella catarrhalis.

Clavulanic acid is a natural inhibitor of beta lactamase which are produced by Streptomyces clavuligerus. It binds to beta lactamase moieties and inactivates them, thus restricting the Cefpodoxime destruction.

Dosage & Administration

Important:
Do not take any medication without a doctor's prescription. Self-medication can be dangerous.
For adults (Age 12 years and older):
  • Acute bacterial exacerbation of chronic bronchitis: 1 tablet 12 hourly for 10 days
  • Acute community acquired pneumonia: 1 tablet 12 hourly for 14 days
  • Pharyngitis or tonsillitis: ½ tablet 12 hourly for 5 to 10 days
  • Skin and soft tissue infections: 2 tablet 12 hourly for 7 to 14 days
  • Urinary tract infections: ½ tablet 12 hourly for 7 days
  • Uncomplicated gonorrhea: Single dose
  • Acute maxillary sinusitis: 1 tablet 12 hourly for 10 days
For children: Children 2 months to 12 years- 10 mg/kg/day in divided dose, every 12 hours.

Interaction

Concomitant administration of Cefpodoxime at high doses with antacids or H2 blockers reduces peak plasma levels of Cefpodoxime.

Contraindications

Cefpodoxime is contraindicated in patients with known hypersensitivity to Cephalosporins.

Side Effects

Cefpodoxime is well tolerated. Most common gastrointestinal adverse effects are diarrhea, vomiting and abdominal pain.

Pregnancy & Lactation

US FDA pregnancy category of Cefpodoxime & Clavulanic Acid is B. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. Cefpodoxime have been shown to be excreted in human milk. So, caution should be exercised when Cefpodoxime is administered to a nursing woman.

Precautions & Warnings

Cefpodoxime should be administered with caution to patients receiving concurrent treatment with diuretics.

Storage Conditions

Keep in a dry place away from light and heat. Keep out of the reach of children.

The information provided on this page is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare professional before starting, stopping, or changing any medication. All brands listed might have copyright or trademark of their respective owners. Listed information may not be up-to-date or accurate. We do not guarantee the availability, quality, price or safety of any medication. Use at your own risk.

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