Ketocid – Amino Acid Ketoanalogues

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Ketocid

600 mg Tablet Other genito-urinary preparations

Amino Acid Ketoanalogues · UniMed UniHealth Pharmaceuticals Ltd.

EN বাং

৳40.00

per unit

AI Summary Generated by AI for informational purposes only

This medicine is a special protein supplement for patients with kidney problems. It helps meet nutritional needs without overloading the kidneys. It should be used during pregnancy and breastfeeding only if prescribed by a doctor.

Indications

Amino Acid Ketoanalogues tablet is indicated for prevention & treatment of damages due to faulty or deficient protein metabolism in chronic kidney disease in connection with a limited dietary protein intake 40 gm/day or less(adult). Usually this applies to patients whose glomerular filtration rate (GFR) is less than 25 ml/min.

Composition

Each film coated tablet contains-

Calcium-3-methyl-2-oxo-valerate (α-ketoanalogue of isoleucine, calcium-salt): 67 mg
Calcium-4-methyl-2-oxo-valerate (α-ketoanalogue of leucine, calcium-salt): 101 mg
Calcium-2-oxo-3-phenylpropionate (α-ketoanalogue of phenylalanine, calcium-salt): 68 mg
Calcium-3-methyl-2-oxobutyrate (α-ketoanalogue of valine, calcium salt): 86 mg
Calcium-DL-2-hydroxy-4-(methylthio) butyrate (α-hydroxyanalogue to methionine, calcium-salt): 59 mg
L-lysine acetate USP (eqv. to Lysine 75mg) :105 mg
L-threonine USP: 53 mg
L-tryptophan USP: 23 mg
L-histidine USP as Histidine Hydrochloride Monohydrate: 38 mg
L-tyrosine USP: 30 mg

Pharmacology

This nutritional supplement contains amino acids, partly in form of there corresponding ketoanalogues, essential for patients with chronic kidney disease. It follows same catabolic pathways as amino acids and works by improving the metabolism of protein in the body, thereby improving the renal function. Amino Acid Ketoanalogues allows the intake of essential amino acids while minimizing the amino-nitrogen intake. The keto- and hydroxy-analogues are transaminated to the corresponding essential amino acids by taking nitrogen from non-essential amino acids, thereby decreasing the formation of urea by re-using the amino group, and causes absorption to occur.

Dosage & Administration

Important:
Do not take any medication without a doctor's prescription. Self-medication can be dangerous.

In general, unless prescribed otherwise, take 4-8 tablets 3 times a day during meals. This dosage applies to adults (with 70 kg body weight).
Swallow whole. The tablets must not be chewed.
Food should contain 40 g/day protein or less (adults).
Ingestion during meals facilitates proper absorption and the metabolisation into the corresponding amino acids.
These tablets are given as long as the GFR is between 5 and about 25mL/minute.

Interaction

Concomitant administration of calcium-containing drugs may cause or aggravate elevated serum calcium levels.
In case of aluminum hydroxide administration, the dose of this drug has to be reduced if necessary.
Drugs that form hardly soluble compounds with calcium (e.g., tetracyclines, quinolones such as ciprofloxacin and norfloxacin as well as drugs containing iron, fluoride or estramustine) should not be taken at the same time with Amino acid keto analogue to avoid disturbed absorption of the active substance. An interval of at least two hours should elapse between the ingestion of Alpha ketoanalogue and these drugs.
The susceptibility to cardioactive glycosides, and hence the risk for arrhythmia will increase in Alpha ketoanalogue.
Monitoring of the serum phosphate levels is needed in case of concomitant administration of aluminum hydroxide.

Contraindications

Hypersensitivity to the active substances or to any of the excipients, Hypercalcemia, disturbed amino acid metabolism.

Side Effects

Hypercalcaemia (Very Rare), If hypercalcaemia occurs, the intake of vitamin D should be reduced. In case of persisting hypercalcaemia, the dose of Amino Acid Keto Analogues as well as the intake of any other calcium sources has to be reduced.

Pregnancy & Lactation

There are no adequate data from the use of Amino Acid Keto Analogues in pregnant women. Animal studies do not indicate direct or indirect harmful effects with respect to pregnancy, embryonal/fetal development, parturition or postnatal development. Caution should be exercised when prescribing to pregnant women. No experience has been made so far with the use during lactation.

Precautions & Warnings

The serum calcium level should be monitored regularly
Ensure sufficient calorie intake
In the presence of hereditary phenylketonuria, attention should be given to the fact that Amino Acid Keto Analogues contains phenylalanine
Monitoring of the serum phosphate levels is needed in case of concomitant administration of aluminium hydroxide

Storage Conditions

Store at a temperature not exceeding 30°C in a dry place. Protect from light & moisture.

The information provided on this page is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare professional before starting, stopping, or changing any medication. All brands listed might have copyright or trademark of their respective owners. Listed information may not be up-to-date or accurate. We do not guarantee the availability, quality, price or safety of any medication. Use at your own risk.

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