AI Summary
Generated by AI for informational purposes only
এটি একটি ঘুমের ঔষধ যা শুধুমাত্র হাসপাতালে, বিশেষ করে আইসিইউ-তে ব্যবহার করা হয়। এটি রোগীদের শান্ত ও আরামে রাখতে সাহায্য করে, বিশেষ করে যখন তারা ভেন্টিলেটরে থাকে। গর্ভাবস্থায় বা স্তন্যদানকালে এর ব্যবহার ডাক্তারেরা জরুরি প্রয়োজন অনুযায়ী নির্ধারণ করেন।
Indications
Dexmedetomidine is a relatively selective alpha2-adrenergic agonist indicated for:
Sedation of initially intubated and mechanically ventilated patients during treatment in an intensive care setting. Administer Dexmedetomidine by continuous infusion not to exceed 24 hours.
Sedation of non-intubated patients prior to and/or during surgical and other procedures.
Pharmacology
Dexmedetomidine is a specific and selective alpha-2 adrenoceptor agonist. By binding to the presynaptic alpha-2 adrenoceptors, it inhibits the release if norepinephrine, therefore, terminate the propagation of pain signals. Activation of the postsynaptic alpha-2 adrenoceptors inhibits the sympathetic activity decreases blood pressure and heart rate.
Dosage & Administration
Important: Do not take any medication without a doctor's prescription. Self-medication can be dangerous.
Individualize and titrate Dexmeditomidine dosing to desired clinical effect.
Administer Dexmeditomidine using a controlled infusion device.
Dilute the 200 mcg/2 mL (100 mcg/mL) vial contents in 0.9% sodium chloride solution to achieve required concentration (4 mcg/mL) prior to administration.
The 200 mcg/50 mL single-use bottles do not require further dilution prior to administration.
For Adult Intensive Care Unit Sedation: Generally initiate at one mcg/kg over 10 minutes, followed by a maintenance infusion of 0.2 to 0.7 mcg/kg/hour.
For Adult Procedural Sedation: Generally initiate at one mcg/kg over 10 minutes, followed by a maintenance infusion initiated at 0.6 mcg/kg/hour and titrated to achieve desired clinical effect with doses ranging from 0.2 to 1 mcg/kg/hour.
Alternative Doses: Recommended for patients over 65 years of age and awake fiberoptic intubation patients.
Interaction
Co-administration of Dexmedetomidine with anesthetics, sedatives, hypnotics, and opioids is likely to lead to an enhancement of effects.
Side Effects
Body as a Whole: Fever, hyperpyrexia, hypovolemia, light anesthesia, pain, rigors Cardiovascular Disorders, General: Blood pressure fluctuation, heart disorder, hypertension, hypotension, myocardial infarction Central and Peripheral Nervous System Disorders: Dizziness, headache, neuralgia, neuritis, speech disorder, convulsion Gastrointestinal System Disorders: Abdominal pain, diarrhea, vomiting, nausea Liver and Biliary System Disorders: Increased gamma-glutamyl transpeptidase, hepatic function abnormal, hyperbilirubinemia Metabolic and Nutritional Disorders: Acidosis, respiratory acidosis, hyperkalemia, thirst, hypoglycemia Psychiatric Disorders: Agitation, confusion, delirium, hallucination, illusion Red Blood Cell Disorders: Anemia Renal Disorders: Blood urea nitrogen increased, oliguria Respiratory System Disorders: Hypoventilation, hypoxia, pulmonary congestion Skin Disorders: Increased sweating Vascular Disorders: Hemorrhage Vision Disorders: Photopsia, abnormal vision.
Pregnancy & Lactation
Pregnancy Category C.
Precautions & Warnings
Continuous monitoring is needed while patient receiving Dexmedetomidine.
Overdose Effects
Bradycardia, hypotension and cardiac arrest is observed.
Storage Conditions
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
The information provided on this page is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
Always consult a qualified healthcare professional before starting, stopping, or changing any medication.
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